Disease

In this conversation on "CBS Eye on the World," John Batchelor and I discuss the development of a universal vaccine to prevent COVID-19. John has received multiple COVID-19 vaccinations and was curious about the concept of a universal vaccine that would protect against all – even future – variants of the virus.
We know the beat of our heart varies over time, increasing with exertion and slowing with rest or meditation. But, stable as those variations may appear, they vary even within those intervals. Dr. George Lundberg, former long-time editor of JAMA, muses about those variations – termed heart rate variability – and what they might tell us.
In order to accurately capture the nuance of an article, especially those about scientific and medical matters, headline writers and editors should read the piece before composing a headline.
We know stress can be dangerous, although treatment is not lacking. Pharmaceuticals abound, and more are in development. But reports are emerging that drugs may be addictive, they don’t work well in mild or moderate cases, and it's hard to wean off them. What’s a patient to do?
The uptake of the current COVID vaccine is running at about 7% of the U.S. population. Pfizer is taking a significant write-off. After the pandemic, our trust in vaccinations has reached a nadir. It's a far cry from our behavior concerning smallpox in 1947 when, over eight days, over 4 million New Yorkers were vaccinated. Or compared to 1961, when 90% of the at-risk population got vaccinated against polio.
While largely ineffective medications for the treatment of Alzheimer’s Disease have gotten a great deal of press, an “orphan” disease – sickle cell disease – is in a similar situation. It is a devastating disease, and there seems to be a gene treatment on the horizon, one that comes with risks and benefits. How do patients calculate what to do?
Answer: It could be. Stress kills. Rarely, but not never. And then there is anxiety, which subsumes a host of related diagnoses. The terms are often co-mingled, with the latter tending to diffuse the dangers of the former. Let’s take a deeper look.
This could be big. All physicians or cancer researchers have been taught forever that a certain class of cancer drugs works by stopping mitosis, hence cancer cell division. However, a group at the University of Wisconsin discovered that everything we thought we knew about drugs like Taxol and vincristine - decades of textbooks - is wrong. The ramifications could reshape cancer drug research.
At the beginning of the year, the CDC and FDA noted “a preliminary safety signal for ischemic stroke among persons aged ≥65 years” who had received the COVID bi-valent vaccine, as well as a similar but "higher" signal in individuals receiving the influenza vaccine at the same time. Now, a study has confirmed that safety signal.
It seems like a bit of common sense: the higher the viral load – in this case of COVID – the greater chance you have to transmit the disease to another. As it turns out, one of the ways we may characterize “infectivity” is when viral load peaks. Omicron infections peak later, and that has clinical implications.
As we age, bones creak, hearing wanes, and cognition diminishes. Promises of rejuvenation have always besieged a vulnerable market seeking the fountain of youth. Now, there seems to be a clinically tested elixir that promises to restore lost brain power – a simple Chinese herbal remedy. So, does it work?
Over the last decade, the Centers for Medicare and Medicaid Services (CMS) launched several initiatives tied to incentives to “providers” to improve care. A peer-reviewed study spins out to interested clinicians the clinical benefits and financial costs of an initiative to reduce cardiovascular disease. The full report to CMS spells out the failures.