Why are some people fully protected by vaccination, or infection-acquired immunity to COVID, when others are not? Does the fault lie with the vaccines? Do some individuals mount a more robust immune response? A new study provides an answer that lies in between those choices and gives me a chance to write about the power and limitations of metaphors.
antigenic sin
“I wear the chain I forged in life,” replied [Morley’s] Ghost. “I made it link by link, and yard by yard.” Our immune system, like those chains, contains our immunologic memories. Ferrets can teach us, that like Morley’s chains, our immunologic memory is forged by experience. Sometimes, a current viral illness may, later on, protect us from a similar viral infection; but we may not be as protected as we hope.