In 1997, the BMJ reported that GlaxoSmithKline had withheld data in a clinical trial, specifically, that Paxil was ineffective in adolescents and often caused suicidal thoughts. From the subsequent justifiable uproar rose ClinicalTrials.gov, a registry for clinical trials requiring the posting of their results when the study was completed. A new study shows that this regulation is routinely ignored. And like a labradoodle, is all bark and no bite.
How can physicians, in the care of their patients, translate research findings into useful information? P-values suggest differences, not effects. But could there be a simple solution?