Hemoglobin Mutation

I spoke recently with John Batchelor (CBS Eye on the World) and Mark Hahn (Drive Time Live, CSCJ Radio) about the recent therapeutic breakthrough in treating Sickle Cell Disease.
Sickle Cell Disease is an awful genetic disease that disproportionally affects black people. It's caused by a single-point mutation in DNA, which results in a modified hemoglobin protein, differing by only one amino acid. While this may sound insignificant, it's anything but. Simple organic chemistry explains why this change profoundly affects those unfortunate enough to inherit the disease, which is characterized by abnormal hemoglobin.