Are COVID Vaccines Responsible for the Variants?

By Josh Bloom — Feb 27, 2022
There’s considerable discussion about whether COVID vaccines are responsible for the barrage of variants that keep hitting us. Is selective pressure driving this – like with bacteria and antibiotics? Let's take a look.

Are COVID vaccines responsible for creating the multiple variants that keep hitting the world? I get this question all the time in the comments section following ACSH articles about vaccines.

It's not an unreasonable question to ask. After all, exposure of bacteria to a given antibiotic will eventually generate strains that are partially or even entirely resistant to that antibiotic. The driving force behind this process is selective pressure – evolution in its most basic form.

The antibiotic will kill most of the bacteria but the bugs naturally mutate, generating large numbers of strains. Most of the new strains will also be susceptible to the antibiotic and not cause problems but eventually, a "new" bug will be formed that will have the ability to survive exposure to the drug by one of several different mechanisms (1). This is a simplified version of how dangerous infections like MRSA came to be.

Is this the same process behind variants like delta and omicron? So far the answer is no. We can demonstrate this by looking at a timeline of the emergence of variants and by looking at one key mutation common to all of the variants.

The problem with the vaccine-variant theory becomes immediately obvious by examining the chart above (Source: WHO). The first person in the world (not including clinical trials) to get vaccinated (Pfizer) was a British grandmother who took the historic step on December 8th, 2020. She was followed shortly thereafter by an American nurse on December 14th. From the WHO chart, we can see that four Variants of Concern (VOC) (plus many variants that never got off the ground) were all documented in the fall of 2020 – at least one month before the first shots. If there is an explanation of how vaccines promoted the formation of variants before they were given I'd like to hear it.

These variants would have occurred anyhow.

There is a fascinating reference site called CoVariants managed by Emma Hodcroft, Ph.D., a postdoctoral fellow at the University of Bern in Switzerland. Hodcroft put together a table of shared mutations, which looks rather menacing at first.

But when we enlarge certain sections of the table, it becomes quite clear. 

Across the top are 11 variants that have been sequenced. Alpha, Beta...Omicron plus a few others. The little colored boxes show the mutations that occur in each variant. I enlarged two boxes. The top box tells that in position 477 (of 1,273 amino acids that make up the spike protein), the amino acid serine has been replaced by asparagine. Underneath, amino acid threonine has been replaced by lysine at position 478. 

Things become rather interesting at position 614:

In all 11 variants, aspartic acid (D) at position 614 is replaced by glycine (G), something I wrote about (See 1 Molecule Of 'Vinegar' And Voila: The Delta Variant) this past July when the Delta variant (the first super contagious variant) was wreaking havoc all over the world. This is no coincidence. The virus (obviously) gains an advantage from this mutation. Of all the mutations listed on the table (there are dozens), D614G is the only one found in all variants. There are a number of theories about why this single mutation has such an impact on the virus (2) but it's not settled yet.

What is settled is that these variants of concern were not caused by any vaccine. Both the timeline and the fact that variants bearing the D614G mutations developed independently worldwide (and sequentially took over from each other) are more than enough evidence to dismiss the vaccine-variant theory. Whatever your feelings are about COVID vaccinations, if you blame Delta and Omicron on vaccines you are spreading false news.

ACSH trustee Dr. Henry Miller, the former director of FDA's Office of Biotechnology and now a Senior Fellow at the Pacific Research Institute goes even further:

I think you need a paragraph something like this: "Far from spurring the appearance of new, more transmissible or virulent SARS-CoV-2 variants, vaccines actually make their appearance far less likely.  Every SARS-CoV-2 infection results in viral replication, the creation of new mutants, and the opportunity for Darwinian evolution to test them for 'fitness' – that is, for greater transmissibility and ability to evade immune defenses. Therefore, as vaccinations suppress infections and lower viral load, the less viral replication, the fewer mutants, and the less likelihood of a new, more evil variant."

Dr. Henry Miller, Private Communication, 2/27/22


(1) Bacteria can defeat antibiotics by a number of mechanisms, such as enzymatically deactivating them or pumping them out of the cell.

(2) Making this even more interesting is that position 614 is nowhere near the receptor-binding domain (RBD). If it were, then the prevalence of this mutation would make sense because you could assume that the mutation makes the mutant viruses bind better. Beats me.

Josh Bloom

Director of Chemical and Pharmaceutical Science

Dr. Josh Bloom, the Director of Chemical and Pharmaceutical Science, comes from the world of drug discovery, where he did research for more than 20 years. He holds a Ph.D. in chemistry.

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