Psychotropic drugs are all the rage now as a potential treatment of brain diseases. Examples are ketamine and psilocybin for depression and PTSD. More recently, a single dose of LSD was found to have a long-lasting effect on generalized anxiety disorder. Some simple chemistry may explain how LSD can persist in the brain long after it is gone from the blood.
breakthrough therapy designation
There's considerable ongoing research to develop analgesic medications that don't have the liabilities of NSAIDs and opioids. Many potential drugs are in various stages of development. Most will fail. This multi-part series will examine drugs in development and their potential utility. First up is VX-458, a Phase III candidate from Vertex.