Roughly 99.5% of people born before 1980 are infected with herpes zoster, yet only 33% will develop its clinical manifestation: shingles. The Institute for Health Metrics and Evaluation estimates that 98% of people in the U.S. have been infected with COVID, but roughly 30% of our population has been symptomatic to the extent that they are registered as “cases.” It's time to discuss the infection enigma - “the puzzling observation that only a small minority of infected people die from infection or even develop clinical disease.”
COVID immunity
A clinical trial of various schedules for administering the two vaccines found that when they were administered together, "the quantitative and functional antibody responses were marginally lower compared to [COVID-19] booster vaccination alone. Lower protection against COVID-19 with concurrent administration of COVID-19 and influenza vaccination cannot be excluded." Thus, the data are somewhat equivocal, but I'll opt to get the two shots at different times.
For many of us, COVID vaccination reduced the severity of illness, but not our becoming infected. We have a hybrid immunity now, tempered by that injectable mRNA of the spike protein and our exposure to real-world COVID. A new study suggests that we, of the hybrid immunity, have a reshaped and more enhanced immune response.