A new study published in JAMA indicates that people who make emergency room visits for pain do just as well with Advil as they do with an opiate. Or do they? The pain devil is in the details. 
A large meta-analysis of high-quality studies published in the Cochrane Library Review showed that topically-applied nonsteroidal anti-inflammatory drugs, or NSAIDs, were just as effective as oral pain pills, but much safer on the gastrointestinal tract.
We tend to think of over the counter (OTC) drugs for pain relief as interchangeable but this can be a dangerous misconception.
A recent study suggesting that ibuprofen and morphine are equally effective for pain management in children with fractures has been gaining a lot of attention in recent days.