We have made amazing progress in the treatment of COVID-19. Two therapies – steroids and remdesivir – have already been shown to help. Those who benefit from these treatments owe thanks to patients who volunteered to participate in controlled clinical trials, and the physicians and pharmaceutical companies that lead them.
As an anti-coronavirus therapy, Remdesivir has been rather disappointing. That's primarily because the drug is given intravenously to those who are already very ill with COVID-19. But what would happen if the drug could be delivered directly to the lungs, to prevent severe disease? Gilead is giving it a shot. Here are some of the pros and cons of that approach.
Somewhere along the way, our achievable goal of "flattening the curve" for COVID-19 has mutated into "finding a cure," which is perhaps an impossible one. Public health and economic policy must be based on reality, not starry-eyed wish-making. Otherwise, people's lives and livelihoods are in grave danger.
Drugs that don't work when taken orally are the bane of drug discovery chemists. Now it's the bane of the world. But there are techniques that can convert orally inactive drugs, like remdesivir, into pills. Here's how they work.
Remdesivir arrived with great hope and even greater expectations. Would this drug finally awake us from the 2-plus-month long nightmare that has the U.S. tossing and turning in its sleep? As things stand now that answer is no. Here's why.
Remdesivir appears to be our first promising treatment for COVID-19. It is certainly neither a cure nor a preventative. But it seems to reduce the length of hospital stays, and thus, increases the health systems’ capacity by about a third. So if you were in charge of selling this drug, what price would you set?
After months of speculation, the results of the first placebo-controlled trial of remdesivir are out. The drug does help people with COVID-19 disease, but it's nothing to get excited about. Here's why.
The first data from the SIMPLE trial of remdesivir has been released by Gilead. Even though this is the first complete trial of the drug, it doesn't answer many questions. That's because there was no control group – something that would have been unethical for the trial participants since they had severe disease. We're just getting started.
It's only one trial, and we don't even know if the report is correct. But a leaked draft report indicated that remdesivir was ineffective in its first controlled trial. Let's assume that this is true and we see the same from other trials. If so, this will not simply be another experimental drug failing. It will be deeply disturbing. Here's why.
Preliminary data, obtained from a randomized clinical trial of remdesivir in China, look bad. Maybe even very bad. But this doesn't mean that the drug won't be shown to be useful in other trials. Nonetheless, not good news.
Remdesivir, the most promising anti-coronavirus drug at this time is no fun to synthesize. But Gilead, the drug's maker, is synthesizing a whole bunch of it. Does this tell us anything about whether the drug works? Maybe.
Early clinical trial results from Gilead show that its antiviral drug, remdesivir, has promise in treating patients with severe COVID-19. Though there are major caveats, there is good reason for cautious optimism.