Former Sen. Kay Hagan Died of Tickborne Powassan Virus. What Is That?

By Alex Berezow, PhD — Oct 29, 2019
Why do microbes kill some people but not others? This is one of the hardest questions to answer in medical microbiology. Here's what we know about the senator's tragic death from the rare tickborne virus.
Credit: Public Domain/Wikipedia

Former Senator Kay Hagan of North Carolina died yesterday at the age of 66 from complications caused by an infection with the Powassan virus. What is that?

Powassan virus is a very rare tickborne infection. When we think of diseases spread by ticks, we usually think of Lyme disease, the most commonly reported one. (About 30,000 cases are reported to the CDC each year, but it's likely that there are roughly 300,000 cases annually.) By comparison, there were only 21 reported cases of Powassan in all of 2018.

A paper published in the journal The Neurohospitalist says that Powassan virus is found both in North America and eastern Russia. It is spread by species of ticks belonging to the genus Ixodes. The tick Ixodes scapularis is particularly nasty, as it spreads not only Powassan but Lyme and several other diseases, such as anaplasmosis, relapsing fever, ehrlichiosis*, and babesiosis.

According to The Neurohospitalist, most infections are thought to be asymptomatic. However, among people who develop symptoms -- which may include serious ones such as meningitis, encephalitis, and seizures -- about 10% will die. There is no vaccine or specific treatment for Powassan, other than to prevent seizures and brain swelling.

The Charlotte Observer reports that Sen. Hagan was hospitalized in December 2016 for encephalitis due to Powassan. The three-year infection and resulting brain inflammation limited her ability to speak and move, and she unexpectedly passed away in her sleep on October 28.

Why her? This is one of the hardest questions not just in philosophy but medical microbiology. The truth is that we don't really know why some diseases cause no symptoms in some but potentially deadly outcomes in others. In my opinion, the most likely explanation is immunogenetic; that is, some people may be susceptible to certain infections because of (currently) unknown genetic profiles that affect a person's immune response.

Unfortunately, we'll never know the exact reason Ms. Hagan died from this rare disease. RIP, Senator.

*Note: Ehrlichiosis was named after German microbiologist Paul Ehrlich, not the unrepentant secular doomsday prophet Paul Ehrlich.


Alex Berezow, PhD

Former Vice President of Scientific Communications

Dr. Alex Berezow is a PhD microbiologist, science writer, and public speaker who specializes in the debunking of junk science for the American Council on Science and Health. He is also a member of the USA Today Board of Contributors and a featured speaker for The Insight Bureau. Formerly, he was the founding editor of RealClearScience.

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