drug resistance

Imagine you’re a firefighter trying to prevent a house from burning to the ground. After many hours of hard work you’ve rescued the family, saved their pet chinchilla and extinguished every visible ember — a job well done. Wouldn’t it be strange if the blaze came roaring back the following day?
Until recently, it looked like the African AIDS epidemic might finally be controlled, with the widespread use of anti-retroviral (ARV) drugs. But poor compliance has caused HIV to mutate in a way such that tenofovir, one of the most important ARV drugs, often no longer works, threatening not only Africa, but world as well.