There's considerable ongoing research to develop analgesic medications that don't have the liabilities of NSAIDs and opioids. Many potential drugs are in various stages of development. Most will fail. This multi-part series will examine drugs in development and their potential utility. First up is VX-458, a Phase III candidate from Vertex.
An important study examining whether antidepressants were useful for pain was recently published in BMJ. The headlines stated varieties of the same theme: They "may not be effective" or "may have a small benefit." These conclusions are based on data from one table in the paper. Let's take a look at that data.