analgesic drugs

There's considerable ongoing research to develop analgesic medications that don't have the liabilities of NSAIDs and opioids. Many potential drugs are in various stages of development. Most will fail. This multi-part series will examine drugs in development and their potential utility. First up is VX-458, a Phase III candidate from Vertex.
An important study examining whether antidepressants were useful for pain was recently published in BMJ. The headlines stated varieties of the same theme: They "may not be effective" or "may have a small benefit." These conclusions are based on data from one table in the paper. Let's take a look at that data.