main protease

Pfizer's Paxlovid looks very promising in fighting COVID. It also provides a good opportunity to learn about how enzyme inhibitors work. For masochists only.
We're almost two years into the pandemic and there have been more than enough ups and downs to last a lifetime. But now we have a potentially big "up," because the results just came in on Pfizer's COVID drug Paxlovid—and they are nothing short of amazing. Will we finally be free of the terror of this pandemic? Maybe.
Antiviral drug development for COVID-19 took a back seat to vaccines during the brief time – when we thought that ending the pandemic was simply a matter of getting enough needles in enough arms. But the virus had other ideas: variants. Now it's looking like we may need a drug to complement the vaccines. Three are in development. Here's a look at Pfizer's PF-07321332. It should work, but don't hold me to that.