A new JAMA Open Network paper concludes that Paxlovid is effective in reducing hospitalizations and deaths in high-risk patients who have been vaccinated or have acquired immunity from previous infections. And a look back at how the drug works its "magic."
The Agency's drug approval and enforcement actions are falling through the cracks, while regulators are squandering time and resources on insubstantial trivia.
The year saw breakthrough articles on highly successful treatments for sickle cell disease, β-thalassemia, rectal cancer, COVID-19, and malaria, and a terrific bionic pancreas for Type 1 diabetics.
There's a new, proven treatment for COVID-19 called pegylated interferon lambda, but FDA won't approve it, even under Emergency Use Authorization. It's inexcusable.
Yet another potential Covid treatment has fallen by the wayside. This time it's fluvoxamine, an antidepressant, which showed some promise in minimizing serious disease in small trials. But in a large, randomized trial, it flopped completely. The lesson? You need an antiviral drug to treat a viral infection – not a repurposed drug. These have all failed.
Let’s continue our countdown of the top articles written by ACSH this year.
Paxlovid, the most effective Covid drug to date has its share of critics. But is the criticism fair? Drs. Henry Miller (an ACSH advisor) and Josh Bloom examine the benefits and limitations of the drug.
News organizations have recently been down on Paxlovid, while it has become the standard of care. Some claim Pfizer's Covid drug "has lost its luster" because of "failures" in two clinical trials. Now, a third trial looks like it could deliver another black mark: the drug doesn't improve symptoms in low-risk patients with Covid. Is this criticism valid? Let's look a little deeper.
There's been a lot of news, some of it fear-mongering, about Pfizer's Covid drug Paxlovid. Some people are having their symptoms return after completing the five-day course. Does that mean there is something wrong with the drug, or it's simply a property of the virus? Drs. Henry Miller and Josh Bloom try to provide an answer in Issues & Insights.
A Boston Globe article describes COVID-19 patients completing a course of Paxlovid – and then becoming ill again shortly thereafter. Is there something wrong with the drug? Is this something to worry about?
Two months ago, there was a mad rush to get the two oral antiviral pills approved to treat COVID-19. Pharmacies often ran out of these drugs within hours of delivery. Now, no one wants them. What is going on?
Should the COVID drug Paxlovid be available without a prescription? Some argue that pharmacists should be able to distribute the drug to people who have tested positive for COVID while others, including the AMA, believe that only physicians should be able to prescribe the drug because of some potentially dangerous drug-drug interactions. Cato Institute's Dr. Jeffrey Singer weighs in.