In March I wrote about Phase IIa results of a novel NSAID-like drug ATB-346 (now called otenaproxesul), which is structurally and functionally similar to naproxen (Aleve). But the non-opioid drug lacks its gastrointestinal side effects, especially ulcers. Now Phase IIb results are in and it still looks good. Will it become the first member of a novel class of pain drugs? We could sure use it. A summary of the company's report to shareholders.
When I wrote about "Magic Aleve" -- a derivative of Aleve/naproxen that appears to be both G.I.-friendly and a more potent analgesic/antiinflammatory than Aleve itself -- a number of questions arose. Dr. John Wallace, CSO of Antibe, which is developing the drug called ATB-346, kindly agreed to answer them.
There hasn't been a material advance in the pharmacological treatment of pain since the 1890s, when heroin and aspirin were invented. That may change if an experimental drug being developed by a Toronto-based drug company keeps performing in advanced clinical trials. This could be huge.
Opioid prohibition spares no one, but the elderly are especially vulnerable. If they're in pain, chances are that they will be sent out of their physician's office with nothing more than Tylenol, which is just about useless. It almost happened to my mother. Yours may not be so fortunate.
The pain relief counter in your pharmacy can be a confusing place ... enough so to give you a headache. But actually, it can all be very simple. There are four over-the-counter painkillers, some of which can be taken together and some of which can't. Here's the scoop, presented in a way that's easy to swallow.
Acetaminophen has become the go-to analgesic for many painful conditions. And when used appropriately, it can be effective for headaches and fever reduction. But it's not useful for inflammatory conditions like arthritis, and it can have a significant downside if used in excess.
A systematic review of controlled clinical trials reveals that opioid analgesics are not superior to non-steroidal anti-inflammatory drugs, or NSAIDs, in treating the pain associated with knee osteoarthritis.
A new study links long-term, continuous use of common painrelievers (NSAIDs and aspirin) to a reduced risk of colorectal cancer (CRC). This study does not prove a cause-and-effect benefit, and these drugs can cause bleeding, so discuss with your doctor.
Disturbing reports about commonly used drugs mean...what? Screening tests over-used, dietary recommendations revamped. In summary: Science Marches On. That s what science is all about, as new data lead to new conclusions for those able to adjust.
Ever since the Vioxx withdrawal in 2004, studies have linked nonsteroidal anti-inflammatory drugs (NSAIDs) to elevated risk of cardiovascular events (CVD). A boxed warning by the FDA on these common painkillers is now going to be augmented with stronger warnings.
We tend to think of over the counter (OTC) drugs for pain relief as interchangeable but this can be a dangerous misconception.