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Negotiating for Medicare drug pricing - will it be the end of the world for Pharma?

It is increasingly clear that Artificial Intelligence (AI) is going to transform our lives in myriad ways, from weather prediction to military planning and in innumerable medical applications. I recently encountered first-hand a new, significant advance – the use of AI to improve the detection of lesions during colonoscopies.

For many complex medical devices such as endoscopes, sterilizing with ethylene oxide is the only method that does the job without damaging the device during the process. Approximately 50% of all sterile medical devices in the U.S. make use of ethylene oxide. The EPA’s ethylene oxide risk assessment demonstrates what happens when faulty data and bad modeling is used as the basis of regulatory policy.

It's not often that one stumbles across one million pennies in their attic. But this is just what happened to a California family. Those folks found sacks of pre-1982 pennies weighing 2.7 tons. Could there be a better time to look at the fascinating and colorful properties of copper? I think not.

Fast fashion refers to quickly designed clothing, easily produced from low-cost (cheap) materials and offered in trendy stores. Zara might be considered a fast fashion’s model. But what becomes of those no longer desirable clothes when the trend changes and the fashion shifts?

How to manage climate change remains a contested policy area, both nationally and internationally. Who will pick up the tab for the changes? One group of scientists has taken the moral high ground, saying “other agents bear substantial responsibility for the cost of redressing climate harm: the companies that engage in the exploration, production, refining, and distribution of oil, gas, and coal.”

Chemistry is hard enough to understand. But this already-convoluted field of science can be even worse because of some stuff that defies logic. Here are five examples.

Economists and policy analysts have long understood that enforcing drug prohibition indirectly increases the drug overdose rate. Now there’s empirical evidence showing it directly increases the overdose rate as well.

Taurine, a dietary supplement, is in the news because of a paper in the journal Science that showed multiple beneficial effects in mice (anti-aging, mental health, weight loss, etc.). Normally, I'm quite skeptical about such claims, but there is some pretty impressive evidence in mouse models, so I'm not so sure. Here's a short lesson on taurine.

There's much discussion about banning gas stove tops because they emit nitrogen dioxide (NO2). Claims are also casually made about these burners with little scientific support about the harmful effects of carbon monoxide, carbon dioxide, and propane/natural gas emissions. Here are some obvious falsehoods and hidden biases in gas stove−childhood asthma research.

For two decades, the Pontifical Academy of Sciences, which advises the Pope on scientific issues, has made wise observations about the importance of molecular techniques for genetic modification and the most appropriate approaches to regulating them. It's a cardinal sin that most of the world has ignored them.

In the Northeast, honeysuckle – perhaps the sweetest smelling flower around – is blooming. It's not just sweet it’s also easily identified. What chemicals make honeysuckle smell so good? You may be surprised.

The media have sounded smoke alarms throughout the Northeast this week, for good reason. We haven’t seen air this bad since the 1960s when heavy (and dirty) fuel oil was the heating medium of choice. The main culprit was particulate matter from black smoke, especially severe in the winter heating seasons. Now we see dirty skies emanating from Canadian forest fires transported by unfavorable wind conditions.

A recent study linking marijuana use to schizophrenia attracted widespread attention. Now that the excitement has died down, let's take a closer look at the science. How does Pfizer's weight-loss pill compare to Ozempic, the obesity treatment beloved by celebrities the world over?

Paratek, an antibiotic biotech first established in 1996 has finally met its end. Its story is long, sad, predictable, predicted and its end completely preventable.

“As the field of transgender health care has transitioned from pathologizing patients to a gender-affirming and patient-centered model and from an understanding of gender as binary to a fuller picture of gender as a spectrum, its associated diagnoses have similarly evolved.” An article in JAMA’s newest spinoff, Journal of Ethics, tries to explore the benefits and problems of a medical diagnosis.

Australia plans to turn e-cigarettes into prescription drugs and will ban people from buying them without a doctor’s prescription. Vaping retailers publicly vow they will move to the underground. We have seen this prohibition movie before. It doesn’t have a happy ending.

New York State's legislators are about to place drastic restrictions on neonicotinoids ("neonics"), a popular, safe, and effective class of pesticides. They're putting the bogus claims of activists ahead of the welfare of consumers and farmers. Let's hope Governor Hochul will be more sensible and veto the bill.

Even as the Surgeon General bemoans the dangers of social media to young people, several states are enacting laws allowing those 14 and over to work without permits, reversing child labor laws enacted almost a century ago. How did we get to the point of curtailing the protection of our most vulnerable segment of the population?

Thalidomide, one of the most infamous drugs of all, caused severe birth defects in the children of pregnant women who took the drug for nausea in the 1950s. Its story has been repeated over and over – mostly wrong. Here's why.

Color me concerned?
Walking About
What does Saudi Arabia have in common with Arizona?
Does the duck-rabbit illusion explain our polarization?

It's finally time to consider Safe and Just Earth System Boundaries proposals to reclaim and reset Earth Systems Boundaries. First up, the three most significant (at least in my view): climate, water, and nutrients. The authors of the paper in Nature challenged us to read their proposals and then discuss them. In the spirit of that challenge, I will let them do the talking.

Let us consider Nature's remaining proposals to reclaim and reset the Biosphere and aerosol pollution. The authors challenged us to read their proposals and then discuss them. In the spirit of that challenge, I have let them do the talking (to be found in the quotes). But I do want to share a few final thoughts.

Russia's decades-old propaganda machine is vast and vicious. Its goal is to damage the health and prosperity of the country's adversaries, especially the United States.

In December, a federal judge dismissed 50,000 Zantac cases because the scientific evidence establishing cancer causation didn’t pass legal muster. In March, a California state judge reached the opposite conclusion. What happens next?